Guanylate Cyclase/metabolism; Natriuretic Peptides/metabolism; Signal Transduction/physiology; Visceral Pain/metabolism; Acetylcholine/pharmacology; Acetylglucosamine/analogs & derivatives; Acetylglucosamine/pharmacology; Adenocarcinoma/pathology; Animals; Cell Differentiation/drug effects; Cell Line, Tumor; Colitis/chemically induced; Colitis/complications; Colon/drug effects; Colon/metabolism; Colorectal Neoplasms/pathology; Cyclic GMP/analogs & derivatives; Cyclic GMP/metabolism; Cyclic GMP/pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Gastrointestinal Diseases/complications; Gastrointestinal Diseases/etiology; Gene Expression Regulation, Neoplastic/drug effects; Humans; Hyperalgesia/physiopathology; Intestinal Mucosa/drug effects; Intestinal Mucosa/metabolism; Intestinal Mucosa/physiology; Male; Mast Cells/drug effects; Mast Cells/metabolism; Morphine/therapeutic use; Multidrug Resistance-Associated Proteins/genetics; Multidrug Resistance-Associated Proteins/metabolism; Natriuretic Peptides/therapeutic use; Organic Anion Transporters, Sodium-Independent/genetics; Organic Anion Transporters, Sodium-Independent/metabolism; Peroxidase/metabolism; RNA, Messenger; Rats; Rats, Sprague-Dawley; Rats, Wistar; Restraint, Physical; Trinitrobenzenesulfonic Acid/toxicity; Visceral Pain/drug therapy; Visceral Pain/etiology

Cyclic guanosine monophosphate; Gastrointestinal pain; Guanylate cyclase-C; Linaclotide; Uroguanylin