CHOP-mediated hepcidin suppression modulates hepatic iron load.

Mueller, Katrin; Sunami, Yoshiaki; Stuetzle, Michael; Guldiken, Nurdan; Kucukoglu, Ozlem; Mueller, Sebastian; Kulaksiz, Hasan; Schwarz, Peggy; Strnad, Pavel

Mueller, Katrin; Sunami, Yoshiaki; Stuetzle, Michael; Guldiken, Nurdan; Kucukoglu, Ozlem; Mueller, Sebastian; Kulaksiz, Hasan; Schwarz, Peggy; Strnad, Pavel.

Affiliation

Mueller K; Department of Internal Medicine I, University Hospital Ulm, Germany.

J Pathol ; 231(4): 532-42, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23749468

Subject(s)

Hepcidins/biosynthesis; Iron Overload/etiology; Liver Cirrhosis, Experimental/complications; Liver Diseases, Alcoholic/complications; Transcription Factor CHOP/physiology; Animals; CCAAT-Enhancer-Binding Protein-alpha/biosynthesis; CCAAT-Enhancer-Binding Protein-alpha/genetics; Carbon Tetrachloride; Female; Gene Expression Regulation/drug effects; Gene Knockout Techniques; Hepcidins/genetics; Humans; Iron/metabolism; Iron Overload/metabolism; Liver/metabolism; Liver Cirrhosis, Experimental/chemically induced; Liver Cirrhosis, Experimental/metabolism; Liver Diseases, Alcoholic/metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger/genetics; Signal Transduction/drug effects; Thioacetamide; Transcription Factor CHOP/biosynthesis; Transcription Factor CHOP/deficiency; Transcription Factor CHOP/genetics

Key words

C/EBPα; CHOP; alcoholic liver disease; fibrosis; hepcidin

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Full text: 1 Database: MEDLINE Main subject: Iron Overload / Transcription Factor CHOP / Hepcidins / Liver Cirrhosis, Experimental / Liver Diseases, Alcoholic Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2013 Type: Article

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