Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice.

Shih, Diana M; Shaposhnik, Zory; Meng, Yonghong; Rosales, Melenie; Wang, Xuping; Wu, Judy; Ratiner, Boris; Zadini, Filiberto; Zadini, Giorgio; Lusis, Aldons J

Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice.

Shih, Diana M; Shaposhnik, Zory; Meng, Yonghong; Rosales, Melenie; Wang, Xuping; Wu, Judy; Ratiner, Boris; Zadini, Filiberto; Zadini, Giorgio; Lusis, Aldons J.

Affiliation

Shih DM; Division of Cardiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave., A2-237 CHS, Los Angeles, CA 90095-1679, USA. dshih@mednet.ucla.edu

FASEB J ; 27(9): 3805-17, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23752203

Subject(s)

Atherosclerosis/metabolism; Atherosclerosis/prevention & control; Deoxycholic Acid/therapeutic use; Lipoproteins, HDL/blood; Receptors, LDL/deficiency; Animals; Cholesterol, HDL/blood; Cholesterol, LDL/blood; Cholesterol, VLDL/blood; Female; Intestinal Absorption/drug effects; Lipoproteins, LDL/blood; Mice; Mice, Knockout; Receptors, LDL/genetics

Key words

bile acid; high-density lipoprotein; intestinal cholesterol absorption; low-density lipoprotein; reverse cholesterol transport

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Full text: 1 Database: MEDLINE Main subject: Receptors, LDL / Deoxycholic Acid / Atherosclerosis / Lipoproteins, HDL Limits: Animals Language: En Year: 2013 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Receptors, LDL / Deoxycholic Acid / Atherosclerosis / Lipoproteins, HDL Limits: Animals Language: En Year: 2013 Type: Article