Cryptococcosis-IRIS is associated with lower cryptococcus-specific IFN-Î³ responses before antiretroviral therapy but not higher T-cell responses during therapy.

Chang, Christina C; Lim, Andrew; Omarjee, Saleha; Levitz, Stuart M; Gosnell, Bernadett I; Spelman, Tim; Elliott, Julian H; Carr, William H; Moosa, Mohamed-Yunus S; Ndung'u, Thumbi; Lewin, Sharon R; French, Martyn A

Chang, Christina C; Lim, Andrew; Omarjee, Saleha; Levitz, Stuart M; Gosnell, Bernadett I; Spelman, Tim; Elliott, Julian H; Carr, William H; Moosa, Mohamed-Yunus S; Ndung'u, Thumbi; Lewin, Sharon R; French, Martyn A.

Affiliation

Chang CC; Department of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Australia.

J Infect Dis ; 208(6): 898-906, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23766525

Subject(s)

AIDS-Related Opportunistic Infections/drug therapy; CD4-Positive T-Lymphocytes/immunology; Fungal Proteins/immunology; Immune Reconstitution Inflammatory Syndrome/immunology; Interferon-gamma/immunology; Meningitis, Cryptococcal/immunology; AIDS-Related Opportunistic Infections/immunology; Adult; Anti-Retroviral Agents/therapeutic use; Antifungal Agents/therapeutic use; Antiretroviral Therapy, Highly Active; Chemokine CXCL10/blood; Chemokine CXCL10/immunology; Cryptococcus; Humans; Immune Reconstitution Inflammatory Syndrome/complications; Immune Reconstitution Inflammatory Syndrome/drug therapy; Interferon-gamma/blood; Interleukin-10/blood; Interleukin-10/immunology; Membrane Glycoproteins/immunology; Meningitis, Cryptococcal/complications; Meningitis, Cryptococcal/drug therapy; Multivariate Analysis; Proportional Hazards Models; Prospective Studies; Recombinant Proteins; Risk Factors; South Africa

Key words

antigen-specific T cells; cryptococcal mannoprotein; cryptococcal meningitis; cryptococcosis-associated immune reconstitution inflammatory syndrome; interferon-gamma; whole blood assay

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Full text: 1 Database: MEDLINE Main subject: Fungal Proteins / CD4-Positive T-Lymphocytes / Interferon-gamma / Meningitis, Cryptococcal / AIDS-Related Opportunistic Infections / Immune Reconstitution Inflammatory Syndrome Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Humans Country/Region as subject: Africa Language: En Year: 2013 Type: Article

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