Transcriptome analyses of inhibitor-treated schistosome females provide evidence for cooperating Src-kinase and TGFß receptor pathways controlling mitosis and eggshell formation.

Buro, Christin; Oliveira, Katia C; Lu, Zhigang; Leutner, Silke; Beckmann, Svenja; Dissous, Colette; Cailliau, Katia; Verjovski-Almeida, Sergio; Grevelding, Christoph G

Buro, Christin; Oliveira, Katia C; Lu, Zhigang; Leutner, Silke; Beckmann, Svenja; Dissous, Colette; Cailliau, Katia; Verjovski-Almeida, Sergio; Grevelding, Christoph G.

Affiliation

Buro C; Institute of Parasitology, Justus-Liebig-University Giessen, Giessen, Germany.

PLoS Pathog ; 9(6): e1003448, 2013.

Article in En | MEDLINE | ID: mdl-23785292

Subject(s)

Enzyme Inhibitors/pharmacology; Helminth Proteins/metabolism; Mitosis/drug effects; Oocytes/metabolism; Receptors, Transforming Growth Factor beta/antagonists & inhibitors; Rifabutin/analogs & derivatives; Schistosoma/metabolism; Transcriptome/drug effects; src-Family Kinases/antagonists & inhibitors; Animals; Cricetinae; Female; Helminth Proteins/antagonists & inhibitors; Helminth Proteins/genetics; Mesocricetus; Mitosis/genetics; Oocytes/cytology; Receptors, Transforming Growth Factor beta/genetics; Receptors, Transforming Growth Factor beta/metabolism; Rifabutin/pharmacology; Schistosoma/genetics; Transcriptome/genetics; Xenopus laevis; src-Family Kinases/genetics; src-Family Kinases/metabolism

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Full text: 1 Database: MEDLINE Main subject: Oocytes / Schistosoma / Helminth Proteins / Rifabutin / Receptors, Transforming Growth Factor beta / Src-Family Kinases / Enzyme Inhibitors / Transcriptome / Mitosis Type of study: Prognostic_studies Limits: Animals Language: En Year: 2013 Type: Article

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