Crosstalk between ER stress and immunogenic cell death.
Cytokine Growth Factor Rev
; 24(4): 311-8, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23787159
ABSTRACT
Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible--at least in part--for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin. The molecular pathways whereby some, but not all, cytotoxic agents promote bona fide ICD remain to be fully elucidated. Nevertheless, a central role for the endoplasmic reticulum (ER) stress response has been revealed in all scenarios of ICD described thus far. Hence, components of the ER stress machinery may constitute clinically relevant druggable targets for the induction of ICD. In this review, we will summarize recent findings in the field of ICD research with a special focus on ER stress mechanisms and their implication for cancer therapy.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cell Death
/
Endoplasmic Reticulum
/
Endoplasmic Reticulum Stress
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Year:
2013
Type:
Article