Cell Transformation, Neoplastic; Core Binding Factor Alpha 2 Subunit/metabolism; Leukemia, Myeloid, Acute/metabolism; Leukemia, Myeloid, Acute/pathology; Multiprotein Complexes/metabolism; Oncogene Proteins, Fusion/metabolism; Transcription Factors/metabolism; Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic/genetics; Core Binding Factor Alpha 2 Subunit/chemistry; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/metabolism; Hematopoietic Stem Cells/pathology; Humans; Leukemia, Myeloid, Acute/genetics; Mice; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes/chemistry; Oncogene Proteins, Fusion/chemistry; Point Mutation; Protein Binding; Protein Multimerization; Protein Stability; Protein Structure, Tertiary; RUNX1 Translocation Partner 1 Protein