Sitagliptin therapy enhances the number of circulating angiogenic cells and angiogenesis-evaluations in vitro and in the rat critical limb ischemia model.

Chua, Sarah; Sheu, Jiunn-Jye; Chen, Yung-Lung; Chang, Li-Teh; Sun, Cheuk-Kwan; Leu, Steve; Sung, Hsin-Ching; Tsai, Tzu-Hsien; Chung, Sheng-Ying; Yeh, Kuo-Ho; Cho, Chung-Lung; Kao, Ying-Hsien; Yip, Hon-Kan

Chua, Sarah; Sheu, Jiunn-Jye; Chen, Yung-Lung; Chang, Li-Teh; Sun, Cheuk-Kwan; Leu, Steve; Sung, Hsin-Ching; Tsai, Tzu-Hsien; Chung, Sheng-Ying; Yeh, Kuo-Ho; Cho, Chung-Lung; Kao, Ying-Hsien; Yip, Hon-Kan.

Affiliation

Chua S; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Cytotherapy ; 15(9): 1148-63, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23849976

Subject(s)

Hindlimb/drug effects; Ischemia/drug therapy; Neovascularization, Physiologic/drug effects; Neovascularization, Physiologic/physiology; Pyrazines/pharmacology; Triazoles/pharmacology; Adipose Tissue/drug effects; Adipose Tissue/metabolism; Adipose Tissue/physiopathology; Animals; Arteries/drug effects; Arteries/metabolism; Arteries/physiology; Biomarkers/metabolism; Cell Movement/drug effects; Cell Movement/physiology; Disease Models, Animal; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Endothelial Cells/physiology; Hindlimb/metabolism; Hindlimb/physiology; Ischemia/metabolism; Ischemia/physiopathology; Male; Rats; Rats, Inbred F344; Regional Blood Flow/drug effects; Regional Blood Flow/physiology; Sitagliptin Phosphate; Stem Cells/drug effects; Stem Cells/metabolism; Stem Cells/physiology

Key words

angiogenesis; endothelial progenitor cells; laser Doppler blood flow; sitagliptin

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Full text: 1 Database: MEDLINE Main subject: Pyrazines / Triazoles / Neovascularization, Physiologic / Hindlimb / Ischemia Type of study: Prognostic_studies Limits: Animals Language: En Year: 2013 Type: Article

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