The cGAS-STING pathway for DNA sensing.
Mol Cell
; 51(2): 135-9, 2013 Jul 25.
Article
in En
| MEDLINE
| ID: mdl-23870141
ABSTRACT
The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms of cGAMP generation. Concurrent studies also reveal unique phosphodiester linkages in endogenous cGAMP that distinguish it from microbial cGAMP and other cyclic dinucleotides. Together, these studies provide a new perspective on DNA recognition in the innate immune system.
Full text:
1
Database:
MEDLINE
Main subject:
DNA
/
Biosensing Techniques
/
Second Messenger Systems
/
Membrane Proteins
/
Nucleotidyltransferases
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Year:
2013
Type:
Article