The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

Wang, Yaya; Shaked, Iftach; Stanford, Stephanie M; Zhou, Wenbo; Curtsinger, Julie M; Mikulski, Zbigniew; Shaheen, Zachary R; Cheng, Genhong; Sawatzke, Kristy; Campbell, Amanda M; Auger, Jennifer L; Bilgic, Hatice; Shoyama, Fernanda M; Schmeling, David O; Balfour, Henry H; Hasegawa, Kiminori; Chan, Andrew C; Corbett, John A; Binstadt, Bryce A; Mescher, Matthew F; Ley, Klaus; Bottini, Nunzio; Peterson, Erik J

Wang, Yaya; Shaked, Iftach; Stanford, Stephanie M; Zhou, Wenbo; Curtsinger, Julie M; Mikulski, Zbigniew; Shaheen, Zachary R; Cheng, Genhong; Sawatzke, Kristy; Campbell, Amanda M; Auger, Jennifer L; Bilgic, Hatice; Shoyama, Fernanda M; Schmeling, David O; Balfour, Henry H; Hasegawa, Kiminori; Chan, Andrew C; Corbett, John A; Binstadt, Bryce A; Mescher, Matthew F; Ley, Klaus; Bottini, Nunzio; Peterson, Erik J.

Affiliation

Wang Y; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

Immunity ; 39(1): 111-22, 2013 Jul 25.

Article in En | MEDLINE | ID: mdl-23871208

Subject(s)

Autoimmunity/immunology; Immunity/immunology; Interferon Type I/immunology; Protein Tyrosine Phosphatase, Non-Receptor Type 22/immunology; Toll-Like Receptors/immunology; Animals; Arthritis/genetics; Arthritis/immunology; Autoimmunity/genetics; Cell Line; Cells, Cultured; Colitis/chemically induced; Colitis/genetics; Colitis/immunology; Dextran Sulfate/immunology; HEK293 Cells; Host-Pathogen Interactions/immunology; Humans; Immunity/genetics; Immunoblotting; Interferon Type I/genetics; Interferon Type I/metabolism; Lymphocytic Choriomeningitis/genetics; Lymphocytic Choriomeningitis/immunology; Lymphocytic Choriomeningitis/virology; Lymphocytic choriomeningitis virus/immunology; Lymphocytic choriomeningitis virus/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myeloid Cells/immunology; Myeloid Cells/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 22/metabolism; Reverse Transcriptase Polymerase Chain Reaction; TNF Receptor-Associated Factor 3/genetics; TNF Receptor-Associated Factor 3/immunology; TNF Receptor-Associated Factor 3/metabolism; Toll-Like Receptors/genetics; Toll-Like Receptors/metabolism; Ubiquitination/immunology

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Full text: 1 Database: MEDLINE Main subject: Interferon Type I / Autoimmunity / Toll-Like Receptors / Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Immunity Type of study: Risk_factors_studies Language: En Year: 2013 Type: Article

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