Carcinoma, Squamous Cell/drug therapy; Flavonoids/therapeutic use; Mitogen-Activated Protein Kinases/metabolism; Moraceae/chemistry; Mouth Neoplasms/drug therapy; NF-kappa B/metabolism; Sirtuin 1/metabolism; Antineoplastic Agents, Phytogenic/isolation & purification; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Agents, Phytogenic/therapeutic use; Apoptosis/drug effects; Carcinoma, Squamous Cell/metabolism; Caspase 3/metabolism; Cell Cycle/drug effects; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Dose-Response Relationship, Drug; Flavonoids/isolation & purification; Flavonoids/pharmacology; Humans; Mitochondria/drug effects; Mitochondria/metabolism; Mouth Neoplasms/metabolism; Phytotherapy; Plant Bark; Plant Extracts/chemistry; Plant Extracts/pharmacology; Plant Extracts/therapeutic use; Plant Roots; Protein Kinases/metabolism; Signal Transduction