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Oncogenic PIK3CA gene mutations and HER2/neu gene amplifications determine the sensitivity of uterine serous carcinoma cell lines to GDC-0980, a selective inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2).
English, Diana P; Bellone, Stefania; Cocco, Emiliano; Bortolomai, Ileana; Pecorelli, Sergio; Lopez, Salvatore; Silasi, Dan-Arin; Schwartz, Peter E; Rutherford, Thomas; Santin, Alessandro D.
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  • English DP; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT.
Am J Obstet Gynecol ; 209(5): 465.e1-9, 2013 Nov.
Article in En | MEDLINE | ID: mdl-23891627
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Carcinoma, Papillary / Endometrial Neoplasms / Genes, erbB-2 / Bridged Bicyclo Compounds, Heterocyclic / Phosphatidylinositol 3-Kinases / Class I Phosphatidylinositol 3-Kinases / TOR Serine-Threonine Kinases / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Year: 2013 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Pyrimidines / Carcinoma, Papillary / Endometrial Neoplasms / Genes, erbB-2 / Bridged Bicyclo Compounds, Heterocyclic / Phosphatidylinositol 3-Kinases / Class I Phosphatidylinositol 3-Kinases / TOR Serine-Threonine Kinases / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Year: 2013 Type: Article