Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp.

Coulerie, Paul; Nour, Mohammed; Maciuk, Alexandre; Eydoux, Cécilia; Guillemot, Jean-Claude; Lebouvier, Nicolas; Hnawia, Edouard; Leblanc, Karine; Lewin, Guy; Canard, Bruno; Figadère, Bruno

Coulerie, Paul; Nour, Mohammed; Maciuk, Alexandre; Eydoux, Cécilia; Guillemot, Jean-Claude; Lebouvier, Nicolas; Hnawia, Edouard; Leblanc, Karine; Lewin, Guy; Canard, Bruno; Figadère, Bruno.

Affiliation

Coulerie P; Laboratoire Insulaire du Vivant et de l'Environnement, Université de la Nouvelle-Calédonie, Nouméa, Nouvelle-Calédonie.

Planta Med ; 79(14): 1313-8, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23929244

Subject(s)

Antiviral Agents/pharmacology; Dengue Virus/drug effects; Flavonoids/pharmacology; Plant Extracts/pharmacology; RNA, Viral/drug effects; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Tracheophyta/chemistry; Antiviral Agents/chemistry; Dengue Virus/enzymology; Dengue Virus/genetics; Flavonoids/chemistry; Inhibitory Concentration 50; New Caledonia; Plant Extracts/chemistry; RNA, Viral/metabolism; RNA-Dependent RNA Polymerase/genetics; Structure-Activity Relationship; Viral Nonstructural Proteins/antagonists & inhibitors; Viral Nonstructural Proteins/genetics

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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Flavonoids / RNA-Dependent RNA Polymerase / RNA, Viral / Plant Extracts / Dengue Virus / Tracheophyta Language: En Year: 2013 Type: Article

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