Chronic high glucose induced INS-1ß cell mitochondrial dysfunction: a comparative mitochondrial proteome with SILAC.

Chen, Xiulan; Cui, Ziyou; Wei, Shasha; Hou, Junjie; Xie, Zhensheng; Peng, Xue; Li, Jing; Cai, Tanxi; Hang, Haiying; Yang, Fuquan

Chen, Xiulan; Cui, Ziyou; Wei, Shasha; Hou, Junjie; Xie, Zhensheng; Peng, Xue; Li, Jing; Cai, Tanxi; Hang, Haiying; Yang, Fuquan.

Affiliation

Chen X; Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Proteomics ; 13(20): 3030-9, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23956156

Subject(s)

Glucose/toxicity; Insulin-Secreting Cells/pathology; Isotope Labeling/methods; Mitochondria/pathology; Mitochondrial Proteins/metabolism; Proteome/metabolism; Animals; Blotting, Western; Cell Line; Hyperglycemia/metabolism; Hyperglycemia/pathology; Insulin/metabolism; Insulin Secretion; Insulin-Secreting Cells/drug effects; Insulin-Secreting Cells/metabolism; Insulin-Secreting Cells/ultrastructure; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondria/ultrastructure; Rats

Key words

Cell biology; Diabetes; High glucose; Mitochondria; SILAC; ß-Cell

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Full text: 1 Database: MEDLINE Main subject: Proteome / Mitochondrial Proteins / Insulin-Secreting Cells / Glucose / Isotope Labeling / Mitochondria Limits: Animals Language: En Year: 2013 Type: Article

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