Sox4, EMT programs, and the metastatic progression of breast cancers: mastering the masters of EMT.
Breast Cancer Res
; 15(4): R72, 2013.
Article
in En
| MEDLINE
| ID: mdl-23981787
ABSTRACT
Epithelial-mesenchymal transition (EMT) programs require the expression of a variety of so-called master regulators of EMT, including members of the Snail, Zeb, and Twist transcription factor families. Teleologically, the requirement for such a diverse group of 'master regulators' seems evolutionarily cumbersome, and emerging evidence indicates that these transcription factors do in fact mediate unique and specialized functions, suggesting the existence of higher-order 'masters' that truly direct and coordinate EMT programs. Accordingly, Tiwari and colleagues recently delineated an elegant pathway wherein transforming growth factor-beta stimulates Sox4 expression, which induces that of the histone methyltransferase, Ezh2, thereby reprogramming the epigenome to elicit EMT programs and metastasis of breast cancers. This viewpoint highlights Sox4 as a 'new' master of EMT programs and metastatic breast cancer.
Full text:
1
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Neoplastic
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Epigenesis, Genetic
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SOXC Transcription Factors
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Epithelial-Mesenchymal Transition
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Polycomb Repressive Complex 2
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Mammary Neoplasms, Experimental
Limits:
Animals
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Female
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Humans
Language:
En
Year:
2013
Type:
Article