Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.

Hou, Yuzhu; Lin, Haijiang; Zhu, Linnan; Liu, Zhaoting; Hu, Fanlei; Shi, Jianfeng; Yang, Tao; Shi, Xiaoyun; Zhu, Mingzhao; Godley, Bernard F; Wang, Qiang; Li, Zhanguo; Zhao, Yong

Hou, Yuzhu; Lin, Haijiang; Zhu, Linnan; Liu, Zhaoting; Hu, Fanlei; Shi, Jianfeng; Yang, Tao; Shi, Xiaoyun; Zhu, Mingzhao; Godley, Bernard F; Wang, Qiang; Li, Zhanguo; Zhao, Yong.

Affiliation

Hou Y; State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, and Chinese Academy of Sciences, Beijing, China.

Arthritis Rheum ; 65(11): 2835-46, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23982886

Subject(s)

Arthritis, Experimental/genetics; Arthritis, Experimental/metabolism; Lipopolysaccharides/pharmacology; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Animals; Arthritis, Experimental/immunology; Disease Models, Animal; Fibroblasts/drug effects; Fibroblasts/physiology; Gene Expression Regulation, Enzymologic/drug effects; Gene Expression Regulation, Enzymologic/immunology; High-Temperature Requirement A Serine Peptidase 1; Humans; Incidence; Macrophages/drug effects; Macrophages/physiology; Mice; Mice, Inbred C57BL; NF-kappa B/metabolism; RNA, Messenger/metabolism; Synovial Membrane/cytology; Synovial Membrane/physiology; Toll-Like Receptor 4/metabolism

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Full text: 1 Database: MEDLINE Main subject: Arthritis, Experimental / Serine Endopeptidases / Lipopolysaccharides Type of study: Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2013 Type: Article

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