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Temporal and spatial variation in Anaplasma phagocytophilum infection in Swedish moose (Alces alces).
Malmsten, J; Widén, D Gavier; Rydevik, G; Yon, L; Hutchings, M R; Thulin, C-G; Söderquist, L; Aspan, A; Stuen, S; Dalin, A-M.
Affiliation
  • Malmsten J; Department of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden.
  • Widén DG; Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Rydevik G; Biomathematics and Statistics Scotland, University of Edinburgh, Edinburgh, UK.
  • Yon L; University of Nottingham School of Veterinary Medicine & Science, Sutton Bonington, UK.
  • Hutchings MR; Disease Systems, Scottish Agricultural College, Edinburgh, UK.
  • Thulin CG; Centre for Fish and Wildlife Research, Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden.
  • Söderquist L; Department of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden.
  • Aspan A; Department of Bacteriology, National Veterinary Institute, Uppsala, Sweden.
  • Stuen S; Department of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
  • Dalin AM; Department of Pathology and Wildlife Diseases, National Veterinary Institute, Uppsala, Sweden.
Epidemiol Infect ; 142(6): 1205-13, 2014 Jun.
Article in En | MEDLINE | ID: mdl-24001524
ABSTRACT

SUMMARY:

The occurrence of Anaplasma phagocytophilum was investigated in spleen and serum samples from Swedish moose (Alces alces) in southern Sweden (island and mainland). Samples were analysed for presence of A. phagocytophilum DNA by real-time PCR (n = 263), and for Anaplasma antibodies with ELISA serology (n = 234). All serum samples had antibodies against A. phagocytophilum. The mean DNA-based prevalence was 26·3%, and significant (P < 0·01) temporal, and spatial variation was found. Island moose had significantly (P < 0·001) higher prevalence of A. phagocytophilum DNA than moose from the mainland areas. Two samples were sequenced to determine genetic variation in the 16S rRNA and groESL genes. Genetic sequence similarity with the human granulocytic anaplasmosis agent, equine granulocytic ehrlichiosis agent, and different wildlife-associated A. phagocytophilum variants were observed in the 16S rRNA and groESL genes. Our study shows that moose are exposed to A. phagocytophilum in Sweden, and represent a potential wildlife reservoir of the pathogen.
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Full text: 1 Database: MEDLINE Main subject: Deer / Ehrlichiosis / Anaplasma phagocytophilum Type of study: Risk_factors_studies Limits: Animals Country/Region as subject: Europa Language: En Year: 2014 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Deer / Ehrlichiosis / Anaplasma phagocytophilum Type of study: Risk_factors_studies Limits: Animals Country/Region as subject: Europa Language: En Year: 2014 Type: Article