Dermatologic Agents/pharmacology; Pentacyclic Triterpenes/pharmacology; Plant Extracts/pharmacology; Skin Aging/drug effects; Skin/drug effects; Terminalia; Aged; Animals; Cells, Cultured; Dermatologic Agents/therapeutic use; Elasticity; Female; Fibroblasts/drug effects; Fibroblasts/metabolism; Gene Expression Profiling; Humans; In Vitro Techniques; Keratinocytes/drug effects; Keratinocytes/metabolism; Microcirculation/drug effects; Middle Aged; Oligonucleotide Array Sequence Analysis; Pentacyclic Triterpenes/therapeutic use; Plant Bark; Plant Extracts/therapeutic use; Postmenopause; Regional Blood Flow/drug effects; Sebum/metabolism; Skin/blood supply; Skin/metabolism; Skin Absorption; Swine; Water/metabolism