Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.

Chan, Hua-Chen; Ke, Liang-Yin; Chu, Chih-Sheng; Lee, An-Sheng; Shen, Ming-Yi; Cruz, Miguel A; Hsu, Jing-Fang; Cheng, Kai-Hung; Chan, Hsiu-Chuan Bonnie; Lu, Jonathan; Lai, Wen-Ter; Sawamura, Tatsuya; Sheu, Sheng-Hsiung; Yen, Jeng-Hsien; Chen, Chu-Huang

Chan, Hua-Chen; Ke, Liang-Yin; Chu, Chih-Sheng; Lee, An-Sheng; Shen, Ming-Yi; Cruz, Miguel A; Hsu, Jing-Fang; Cheng, Kai-Hung; Chan, Hsiu-Chuan Bonnie; Lu, Jonathan; Lai, Wen-Ter; Sawamura, Tatsuya; Sheu, Sheng-Hsiung; Yen, Jeng-Hsien; Chen, Chu-Huang.

Affiliation

Chan HC; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;

Blood ; 122(22): 3632-41, 2013 Nov 21.

Article in En | MEDLINE | ID: mdl-24030386

Subject(s)

Lipoproteins, LDL/blood; Myocardial Infarction/blood; Platelet Activation/physiology; Platelet Aggregation/physiology; Animals; Case-Control Studies; Cyclic AMP/blood; Electrochemistry; Endothelial Cells/physiology; Humans; Lipoproteins, LDL/chemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction/etiology; P-Selectin/blood; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Platelet Membrane Glycoproteins/antagonists & inhibitors; Protein Kinase C-alpha/blood; Receptors, G-Protein-Coupled/antagonists & inhibitors; Receptors, G-Protein-Coupled/blood; Scavenger Receptors, Class E/antagonists & inhibitors; Scavenger Receptors, Class E/blood; Scavenger Receptors, Class E/deficiency; Scavenger Receptors, Class E/genetics; Signal Transduction; Thrombosis/blood; Thrombosis/etiology

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Full text: 1 Database: MEDLINE Main subject: Platelet Activation / Platelet Aggregation / Lipoproteins, LDL / Myocardial Infarction Type of study: Etiology_studies / Observational_studies Limits: Animals / Humans / Male Language: En Year: 2013 Type: Article

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