Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration.

Unett, David J; Gatlin, Joel; Anthony, Todd L; Buzard, Daniel J; Chang, Steve; Chen, Chuan; Chen, Xiaohua; Dang, Huong T-M; Frazer, John; Le, Minh K; Sadeque, Abu J M; Xing, Charles; Gaidarov, Ibragim

Unett, David J; Gatlin, Joel; Anthony, Todd L; Buzard, Daniel J; Chang, Steve; Chen, Chuan; Chen, Xiaohua; Dang, Huong T-M; Frazer, John; Le, Minh K; Sadeque, Abu J M; Xing, Charles; Gaidarov, Ibragim.

Affiliation

Unett DJ; Departments of Receptor Pharmacology (D.J.U., X.C., J.G., T.L.A., S.C., H.T.-M.D., J.F., M.K.L., C.X., I.G.), Chemistry (D.J.B.), Drug Metabolism & Pharmacokinetics (C.C., A.J.M.S.), Arena Pharmaceuticals Inc., San Diego, California.

J Pharmacol Exp Ther ; 347(3): 645-59, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24049061

Subject(s)

Receptor, Serotonin, 5-HT2B/drug effects; Serotonin Receptor Agonists/pharmacology; Signal Transduction/drug effects; Adrenergic alpha-Antagonists/pharmacology; Amphetamines/pharmacokinetics; Arrestins/metabolism; Calcium/metabolism; Dose-Response Relationship, Drug; Ergot Alkaloids/pharmacology; Extracellular Signal-Regulated MAP Kinases/metabolism; HEK293 Cells; Humans; Phenoxybenzamine/pharmacology; Phosphorylation; Radioligand Assay; beta-Arrestins

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Serotonin Receptor Agonists / Receptor, Serotonin, 5-HT2B Type of study: Prognostic_studies Limits: Humans Language: En Year: 2013 Type: Article

Fulltext

XML

PubMed Links

Search on Google