Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes.

Hunt, William R; Zughaier, Susu M; Guentert, Dana E; Shenep, Melissa A; Koval, Michael; McCarty, Nael A; Hansen, Jason M

Hunt, William R; Zughaier, Susu M; Guentert, Dana E; Shenep, Melissa A; Koval, Michael; McCarty, Nael A; Hansen, Jason M.

Affiliation

Hunt WR; 2015 Uppergate Dr., Suite 350, Atlanta, GA 30322. jhansen@emory.edu.

Am J Physiol Lung Cell Mol Physiol ; 306(1): L43-9, 2014 Jan 01.

Article in En | MEDLINE | ID: mdl-24097557

Subject(s)

Cystic Fibrosis/complications; Diabetes Mellitus, Experimental/complications; Hyperglycemia/complications; Pneumonia, Bacterial/microbiology; Pseudomonas Infections/microbiology; Pseudomonas aeruginosa/immunology; Animals; Bacterial Load; Bronchoalveolar Lavage Fluid; Cystic Fibrosis/immunology; Cystic Fibrosis/microbiology; Diabetes Mellitus, Experimental/immunology; Diabetes Mellitus, Experimental/microbiology; Disease Models, Animal; Female; Humans; Hyperglycemia/immunology; Hyperglycemia/microbiology; Lung/immunology; Lung/microbiology; Lung/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CFTR; Mice, Knockout; Pneumonia, Bacterial/immunology; Pseudomonas Infections/immunology; Tissue Culture Techniques

Key words

Pseudomonas; cystic fibrosis; cystic fibrosis-related diabetes; murine model; pneumonia

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Full text: 1 Database: MEDLINE Main subject: Pseudomonas aeruginosa / Pseudomonas Infections / Pneumonia, Bacterial / Cystic Fibrosis / Diabetes Mellitus, Experimental / Hyperglycemia Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2014 Type: Article

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