Your browser doesn't support javascript.
loading
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.
Immunity ; 39(4): 770-81, 2013 Oct 17.
Article in En | MEDLINE | ID: mdl-24138884
ABSTRACT
Follicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5⁺ CD4⁺ T cells in humans and mice, the CCR7(lo)PD-1(hi) subset has a partial Tfh effector phenotype, whereas CCR7(hi)PD-1(lo) cells have a resting phenotype. The circulating CCR7(lo)PD-1(hi) subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7(lo)PD-1(hi) subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7(hi)PD-1(lo) and CCR7(lo)PD-1(hi) subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5⁺ helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7(lo)PD-1(hi) CXCR5⁺ precursors rapidly differentiate into mature Tfh cells to promote antibody responses. Therefore, circulating CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory.
Subject(s)

Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Helper-Inducer / Receptors, CXCR / Receptors, CXCR5 / Programmed Cell Death 1 Receptor / Immunologic Memory / Antibodies Limits: Animals / Humans Language: En Year: 2013 Type: Article

Full text: 1 Database: MEDLINE Main subject: T-Lymphocytes, Helper-Inducer / Receptors, CXCR / Receptors, CXCR5 / Programmed Cell Death 1 Receptor / Immunologic Memory / Antibodies Limits: Animals / Humans Language: En Year: 2013 Type: Article