Deletion of airway cilia results in noninflammatory bronchiectasis and hyperreactive airways.

Gilley, Sandra K; Stenbit, Antine E; Pasek, Raymond C; Sas, Kelli M; Steele, Stacy L; Amria, May; Bunni, Marlene A; Estell, Kimberly P; Schwiebert, Lisa M; Flume, Patrick; Gooz, Monika; Haycraft, Courtney J; Yoder, Bradley K; Miller, Caroline; Pavlik, Jacqueline A; Turner, Grant A; Sisson, Joseph H; Bell, P Darwin

Gilley, Sandra K; Stenbit, Antine E; Pasek, Raymond C; Sas, Kelli M; Steele, Stacy L; Amria, May; Bunni, Marlene A; Estell, Kimberly P; Schwiebert, Lisa M; Flume, Patrick; Gooz, Monika; Haycraft, Courtney J; Yoder, Bradley K; Miller, Caroline; Pavlik, Jacqueline A; Turner, Grant A; Sisson, Joseph H; Bell, P Darwin.

Affiliation

Gilley SK; 70 President St, DDB520, MUSC, Charleston, SC 29425. Bellpd@musc.edu.

Am J Physiol Lung Cell Mol Physiol ; 306(2): L162-9, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24213915

Subject(s)

Bronchial Hyperreactivity/pathology; Bronchiectasis/pathology; Cilia/pathology; Cilia/physiology; Ciliary Motility Disorders/pathology; Animals; Bronchial Hyperreactivity/physiopathology; Bronchiectasis/physiopathology; Bronchoconstrictor Agents/pharmacology; Ciliary Motility Disorders/physiopathology; Disease Models, Animal; Methacholine Chloride/pharmacology; Mice; Mice, Knockout; Mucociliary Clearance/physiology; Respiratory Mucosa/drug effects; Respiratory Mucosa/pathology; Respiratory Mucosa/physiopathology; Tumor Suppressor Proteins/genetics

Key words

bronchiectasis; hyperreactivity; lung; respiratory

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Full text: 1 Database: MEDLINE Main subject: Bronchiectasis / Cilia / Ciliary Motility Disorders / Bronchial Hyperreactivity Limits: Animals Language: En Year: 2014 Type: Article

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