Trail overexpression inversely correlates with histological differentiation in intestinal-type sinonasal adenocarcinoma.
Int J Surg Oncol
; 2013: 203873, 2013.
Article
in En
| MEDLINE
| ID: mdl-24223304
ABSTRACT
INTRODUCTION:
Despite their histological resemblance to colorectal adenocarcinoma, there is some information about the molecular events involved in the pathogenesis of intestinal-type sinonasal adenocarcinomas (ITACs). To evaluate the possible role of TNF-related apoptosis-inducing ligand (TRAIL) gene defects in ITAC, by investigating the immunohistochemical expression of TRAIL gene product in a group of ethmoidal ITACs associated with occupational exposure. MATERIAL ANDMETHODS:
Retrospective study on 23 patients with pathological diagnosis of primary ethmoidal ITAC. Representative formalin-fixed, paraffin-embedded block from each case was selected for immunohistochemical studies using the antibody against TRAIL. Clinicopathological data were also correlated with the staining results.RESULTS:
The immunohistochemical examination demonstrated that poorly differentiated cases showed a higher percentage of TRAIL expressing cells compared to well-differentiated cases. No correlation was found with other clinicopathological parameters, including T, stage and relapses.CONCLUSION:
The relationship between upregulation of TRAIL and poorly differentiated ethmoidal adenocarcinomas suggests that the mutation of this gene, in combination with additional genetic events, could play a role in the pathogenesis of ITAC.
Full text:
1
Database:
MEDLINE
Main subject:
Paranasal Sinus Neoplasms
/
Adenocarcinoma
/
Ethmoid Sinus
/
TNF-Related Apoptosis-Inducing Ligand
/
Occupational Diseases
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2013
Type:
Article