Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein.

Mincheva-Tasheva, Stefka; Obis, Elia; Tamarit, Jordi; Ros, Joaquim

Mincheva-Tasheva, Stefka; Obis, Elia; Tamarit, Jordi; Ros, Joaquim.

Affiliation

Mincheva-Tasheva S; Grup de Bioquímica de L'Estrès Oxidatiu, Departament de Ciències Mèdiques Bàsiques, IRB Lleida, Universitat de Lleida, Lleida, Spain.

Hum Mol Genet ; 23(7): 1829-41, 2014 Apr 01.

Article in En | MEDLINE | ID: mdl-24242291

Subject(s)

Apoptosis/genetics; Ganglia, Spinal/cytology; Iron-Binding Proteins/genetics; Sensory Receptor Cells/cytology; bcl-X Protein/genetics; Animals; Calcium/metabolism; Calcium Signaling/genetics; Cells, Cultured; Friedreich Ataxia/genetics; Gene Products, tat/genetics; Homeostasis; Iron-Binding Proteins/biosynthesis; Iron-Binding Proteins/metabolism; Membrane Potential, Mitochondrial/genetics; Mitochondrial Proteins/metabolism; Neurites/pathology; Neurodegenerative Diseases; Protein Structure, Tertiary/genetics; RNA Interference; RNA, Small Interfering; Rats; Frataxin

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Full text: 1 Database: MEDLINE Main subject: Sensory Receptor Cells / Apoptosis / Iron-Binding Proteins / Bcl-X Protein / Ganglia, Spinal Limits: Animals Language: En Year: 2014 Type: Article

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