Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues.

Hammond, Edward; Handley, Paul; Dredge, Keith; Bytheway, Ian

Hammond, Edward; Handley, Paul; Dredge, Keith; Bytheway, Ian.

Affiliation

Hammond E; Progen Pharmaceuticals, Darra, QLD 4076, Australia.

FEBS Open Bio ; 3: 346-51, 2013.

Article in En | MEDLINE | ID: mdl-24251094

Key words

Cancer; ECM, extracellular matrix; HS, heparan sulfate; HSPG, heparan sulfate proteoglycan; Heparanase; Inhibitor; Kinetics; PG545; SE, standard error; SS, sum of squares; WST-1, 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate

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