Chirally deuterated benzyl chlorides from benzyl alcohols via hexachloroacetone/polymer-supported triphenylphosphine: synthesis of protected (2S, 3S)-[3-(2)H, (15)N]-tyrosine.

Barnett, Derek W; Refaei, Maryanne S; Curley, Robert W

Barnett, Derek W; Refaei, Maryanne S; Curley, Robert W.

Affiliation

Barnett DW; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA.

J Labelled Comp Radiopharm ; 56(1): 6-11, 2013 Jan.

Article in En | MEDLINE | ID: mdl-24285134

Subject(s)

Benzyl Compounds/chemical synthesis; Deuterium/chemistry; Tyrosine/chemical synthesis; Acetone/analogs & derivatives; Acetone/chemical synthesis; Acetone/chemistry; Benzyl Alcohols/chemical synthesis; Benzyl Alcohols/chemistry; Benzyl Compounds/chemistry; Nitrogen Isotopes/chemistry; Organophosphorus Compounds/chemical synthesis; Organophosphorus Compounds/chemistry; Polymers/chemistry; Tyrosine/chemistry

Key words

alcohols; benzylic; chiral; chlorides; deuteration; tyrosine

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