Agonistic anti-human Fas monoclonal antibody induces fibroblast-like synoviocyte apoptosis in haemophilic arthropathy: potential therapeutic implications.

Romano, E; Manetti, M; Peruzzi, F; Melchiorre, D; Milia, A F; Bellando-Randone, S; Nishioka, K; Innocenti, M; Carulli, C; Linari, S; Morfini, M; Ibba-Manneschi, L; Matucci-Cerinic, M; Guiducci, S

Romano, E; Manetti, M; Peruzzi, F; Melchiorre, D; Milia, A F; Bellando-Randone, S; Nishioka, K; Innocenti, M; Carulli, C; Linari, S; Morfini, M; Ibba-Manneschi, L; Matucci-Cerinic, M; Guiducci, S.

Affiliation

Romano E; Section of Internal Medicine, Division of Rheumatology, Department of Experimental and Clinical Medicine, Azienda Ospedaliero-Universitaria Careggi, and DENOthe Centre, University of Florence, Florence, Italy.

Haemophilia ; 20(1): e32-9, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24308756

Subject(s)

Antibodies, Monoclonal/pharmacology; Apoptosis/drug effects; Fibroblasts/drug effects; Hemarthrosis/etiology; Hemophilia A/complications; Synovial Membrane/drug effects; Synovial Membrane/pathology; Adult; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid/metabolism; Caspase 3/metabolism; Cell Survival/drug effects; Fibroblasts/metabolism; Hemarthrosis/metabolism; Hemarthrosis/pathology; Humans; Immunoglobulin M/immunology; Immunoglobulin M/pharmacology; Male; Middle Aged; Synovial Membrane/metabolism; Young Adult; fas Receptor/immunology; fas Receptor/metabolism

Key words

agonistic anti-Fas IgM antibody; apoptosis; fibroblast-like synoviocytes; haemophilic arthropathy; synovitis

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Full text: 1 Database: MEDLINE Main subject: Synovial Membrane / Apoptosis / Fibroblasts / Hemarthrosis / Hemophilia A / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Adult / Humans / Male / Middle aged Language: En Year: 2014 Type: Article

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