The return of the nucleus: transcriptional and epigenetic control of autophagy.
Nat Rev Mol Cell Biol
; 15(1): 65-74, 2014 01.
Article
in En
| MEDLINE
| ID: mdl-24326622
ABSTRACT
Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigenetic network that regulates autophagy. The identification of tightly controlled transcription factors (such as TFEB and ZKSCAN3), microRNAs and histone marks (especially acetylated Lys16 of histone 4 (H4K16ac) and dimethylated H3K9 (H3K9me2)) associated with the autophagic process offers an attractive conceptual framework to understand the short-term transcriptional response and potential long-term responses to autophagy.
Full text:
1
Database:
MEDLINE
Main subject:
Autophagy
/
Cell Nucleus
/
Epigenesis, Genetic
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Year:
2014
Type:
Article