Napyradiomycin derivatives, produced by a marine-derived actinomycete, illustrate cytotoxicity by induction of apoptosis.

Farnaes, Lauge; Coufal, Nicole G; Kauffman, Christopher A; Rheingold, Arnold L; DiPasquale, Antonio G; Jensen, Paul R; Fenical, William

Farnaes, Lauge; Coufal, Nicole G; Kauffman, Christopher A; Rheingold, Arnold L; DiPasquale, Antonio G; Jensen, Paul R; Fenical, William.

Affiliation

Farnaes L; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego , La Jolla, California 92093-0204, United States.

J Nat Prod ; 77(1): 15-21, 2014 Jan 24.

Article in En | MEDLINE | ID: mdl-24328269

Subject(s)

Antineoplastic Agents/isolation & purification; Antineoplastic Agents/pharmacology; Apoptosis/drug effects; Naphthoquinones/isolation & purification; Naphthoquinones/pharmacology; Antineoplastic Agents/chemistry; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Marine Biology; Molecular Conformation; Molecular Structure; Naphthoquinones/chemistry; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism

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Full text: 1 Database: MEDLINE Main subject: Naphthoquinones / Apoptosis / Antineoplastic Agents Limits: Humans Language: En Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Naphthoquinones / Apoptosis / Antineoplastic Agents Limits: Humans Language: En Year: 2014 Type: Article