Postresuscitation administration of doxycycline preserves cardiac contractile function in hypoxia-reoxygenation injury of newborn piglets*.

LaBossiere, Joseph R; Pelletier, Jean-Sebastian; Ali, Mohammad A; Thiesen, Aducio; Schulz, Richard; Bigam, David L; Cheung, Po-Yin

LaBossiere, Joseph R; Pelletier, Jean-Sebastian; Ali, Mohammad A; Thiesen, Aducio; Schulz, Richard; Bigam, David L; Cheung, Po-Yin.

Affiliation

LaBossiere JR; 1Department of Surgery, University of Alberta, Edmonton, AB, Canada. 2Department of Pharmacology, University of Alberta, Edmonton, AB, Canada. 3Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada. 4Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Crit Care Med ; 42(4): e260-9, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24335448

Subject(s)

Doxycycline/administration & dosage; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors/administration & dosage; Myocardial Reperfusion Injury/prevention & control; Resuscitation/methods; Acidosis/physiopathology; Animals; Animals, Newborn; Cardiac Output; Dose-Response Relationship, Drug; Hemodynamics; Hypotension/physiopathology; Myocardial Reperfusion Injury/pathology; Oxidative Stress/physiology; Random Allocation; Shock, Cardiogenic/physiopathology; Swine; Troponin I/metabolism

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Full text: 1 Database: MEDLINE Main subject: Resuscitation / Myocardial Reperfusion Injury / Doxycycline / Matrix Metalloproteinase 2 / Matrix Metalloproteinase Inhibitors Limits: Animals Language: En Year: 2014 Type: Article

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