Regorafenib (BAY 73-4506): antitumor and antimetastatic activities in preclinical models of colorectal cancer.

Schmieder, Roberta; Hoffmann, Jens; Becker, Michael; Bhargava, Ajay; Müller, Tina; Kahmann, Nicole; Ellinghaus, Peter; Adams, Robert; Rosenthal, André; Thierauch, Karl-Heinz; Scholz, Arne; Wilhelm, Scott M; Zopf, Dieter

Schmieder, Roberta; Hoffmann, Jens; Becker, Michael; Bhargava, Ajay; Müller, Tina; Kahmann, Nicole; Ellinghaus, Peter; Adams, Robert; Rosenthal, André; Thierauch, Karl-Heinz; Scholz, Arne; Wilhelm, Scott M; Zopf, Dieter.

Affiliation

Schmieder R; Bayer Pharma AG, Berlin, Germany.

Int J Cancer ; 135(6): 1487-96, 2014 Sep 15.

Article in En | MEDLINE | ID: mdl-24347491

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/pharmacology; Colorectal Neoplasms/drug therapy; Phenylurea Compounds/pharmacology; Pyridines/pharmacology; Animals; Camptothecin/administration & dosage; Camptothecin/analogs & derivatives; Cell Growth Processes/drug effects; Cell Line, Tumor; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Drug Resistance, Neoplasm; Female; Humans; Irinotecan; Liver Neoplasms, Experimental/drug therapy; Liver Neoplasms, Experimental/metabolism; Liver Neoplasms, Experimental/secondary; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Metastasis; Organoplatinum Compounds/pharmacology; Oxaliplatin; Phenylurea Compounds/administration & dosage; Pyridines/administration & dosage; Random Allocation; Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-2/metabolism; Vascular Endothelial Growth Factor Receptor-3/antagonists & inhibitors; Vascular Endothelial Growth Factor Receptor-3/metabolism; Xenograft Model Antitumor Assays

Key words

CRC; antimetastasis; antitumorigenesis; multikinase inhibitor; regorafenib

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Full text: 1 Database: MEDLINE Main subject: Phenylurea Compounds / Pyridines / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Year: 2014 Type: Article

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