The sclerostin-independent bone anabolic activity of intermittent PTH treatment is mediated by T-cell-produced Wnt10b.

Li, Jau-Yi; Walker, Lindsey D; Tyagi, Abdul Malik; Adams, Jonathan; Weitzmann, M Neale; Pacifici, Roberto

Li, Jau-Yi; Walker, Lindsey D; Tyagi, Abdul Malik; Adams, Jonathan; Weitzmann, M Neale; Pacifici, Roberto.

Affiliation

Li JY; Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.

J Bone Miner Res ; 29(1): 43-54, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24357520

Subject(s)

Glycoproteins/antagonists & inhibitors; Parathyroid Hormone/administration & dosage; Wnt Proteins/biosynthesis; Adaptor Proteins, Signal Transducing; Animals; Antibodies/pharmacology; Bone Density/drug effects; Bone and Bones/drug effects; Female; Glycoproteins/biosynthesis; Glycoproteins/immunology; Intercellular Signaling Peptides and Proteins; Mice; Osteoblasts/drug effects; Osteogenesis/drug effects; T-Lymphocytes/metabolism

Key words

ANTIBODY; BONE; PTH; SCL; T CELLS; WNT10B

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Full text: 1 Database: MEDLINE Main subject: Parathyroid Hormone / Glycoproteins / Wnt Proteins Type of study: Prognostic_studies Limits: Animals Language: En Year: 2014 Type: Article

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