Validated LC-MS/MS method for the simultaneous determination of hyperoside and 2''-O-galloylhyperin in rat plasma: application to a pharmacokinetic study in rats.

Zhou, Donghui; Jin, Yuanzhe; Yao, Fengchen; Duan, Zhiying; Wang, Qi; Liu, Jing

Zhou, Donghui; Jin, Yuanzhe; Yao, Fengchen; Duan, Zhiying; Wang, Qi; Liu, Jing.

Affiliation

Zhou D; Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, Liaoning, China.

Biomed Chromatogr ; 28(8): 1057-63, 2014 Aug.

Article in En | MEDLINE | ID: mdl-24375731

Subject(s)

Chromatography, Liquid/methods; Gallic Acid/analogs & derivatives; Quercetin/analogs & derivatives; Tandem Mass Spectrometry/methods; Animals; Drug Stability; Gallic Acid/blood; Gallic Acid/chemistry; Gallic Acid/pharmacokinetics; Limit of Detection; Linear Models; Male; Quercetin/blood; Quercetin/chemistry; Quercetin/pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results

Key words

2''-O-galloylhyperin; LC-MS/MS; hyperoside; pharmacokinetic study; simultaneous determination

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Full text: 1 Database: MEDLINE Main subject: Quercetin / Chromatography, Liquid / Tandem Mass Spectrometry / Gallic Acid Type of study: Prognostic_studies Limits: Animals Language: En Year: 2014 Type: Article

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