Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate.

Honda, Masayoshi; Okuno, Yusuke; Hengel, Sarah R; Martín-López, Juana V; Cook, Christopher P; Amunugama, Ravindra; Soukup, Randal J; Subramanyam, Shyamal; Fishel, Richard; Spies, Maria

Honda, Masayoshi; Okuno, Yusuke; Hengel, Sarah R; Martín-López, Juana V; Cook, Christopher P; Amunugama, Ravindra; Soukup, Randal J; Subramanyam, Shyamal; Fishel, Richard; Spies, Maria.

Affiliation

Honda M; Department of Biochemistry, University of Iowa, Iowa City, IA 52242.

Proc Natl Acad Sci U S A ; 111(3): E316-25, 2014 Jan 21.

Article in En | MEDLINE | ID: mdl-24395779

Subject(s)

DNA Mismatch Repair; DNA-Binding Proteins/chemistry; DNA/chemistry; MutS Homolog 2 Protein/chemistry; Recombination, Genetic; Adenosine Diphosphate/chemistry; Adenosine Triphosphate/chemistry; Base Pair Mismatch; Biotinylation; Humans; Hydrolysis; Kinetics; Protein Binding; Protein Structure, Tertiary; Rad51 Recombinase/chemistry; Replication Protein A/chemistry

Key words

homeologous recombination; homologous recombination; mismatch DNA repair; single-molecule; total internal reflection fluorescence microscopy

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Full text: 1 Database: MEDLINE Main subject: Recombination, Genetic / DNA / DNA-Binding Proteins / MutS Homolog 2 Protein / DNA Mismatch Repair Limits: Humans Language: En Year: 2014 Type: Article

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