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A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial.
Axelsen, Mette Bjørndal; Eshed, Iris; Hørslev-Petersen, Kim; Stengaard-Pedersen, Kristian; Hetland, Merete Lund; Møller, Jakob; Junker, Peter; Pødenphant, Jan; Schlemmer, Annette; Ellingsen, Torkell; Ahlquist, Palle; Lindegaard, Hanne; Linauskas, Asta; Dam, Mette Yde; Hansen, Ib; Horn, Hans Christian; Ammitzbøll, Christian Gytz; Jørgensen, Anette; Krintel, Sophine B; Raun, Johnny; Krogh, Niels S; Johansen, Julia Sidenius; Østergaard, Mikkel.
Affiliation
  • Axelsen MB; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.
  • Eshed I; Department of Radiology, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel.
  • Hørslev-Petersen K; King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.
  • Stengaard-Pedersen K; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
  • Hetland ML; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheu
  • Møller J; Department of Radiology, Copenhagen University Hospital at Herlev, Copenhagen, Denmark.
  • Junker P; Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
  • Pødenphant J; Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Schlemmer A; Department of Rheumatology, Aarhus University Hospital in Aalborg, Aalborg, Denmark.
  • Ellingsen T; Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.
  • Ahlquist P; Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.
  • Lindegaard H; Department of Rheumatology C, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
  • Linauskas A; Department of Rheumatology, Vendsyssel Hospital, Hjørring, Denmark.
  • Dam MY; Diagnostic Centre, Silkeborg Regional Hospital, Silkeborg, Denmark.
  • Hansen I; Department of Rheumatology, Viborg Regional Hospital, Viborg, Denmark.
  • Horn HC; Department of Medicine, Vejle Regional Hospital, Vejle, Denmark.
  • Ammitzbøll CG; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
  • Jørgensen A; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
  • Krintel SB; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark.
  • Raun J; King Christian 10th Hospital for Rheumatic Diseases, Gråsten, Denmark South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, Denmark.
  • Krogh NS; Zitelabs Aps, Copenhagen, Denmark.
  • Johansen JS; Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark Department of Medicine and Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.
  • Østergaard M; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark Faculty of Health and Medical Sciences, Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark The DANBIO Registry, Center for Rheu
Ann Rheum Dis ; 74(5): 867-75, 2015 May.
Article in En | MEDLINE | ID: mdl-24412895
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Full text: 1 Database: MEDLINE Main subject: Arthritis, Rheumatoid / Triamcinolone / Methotrexate / Antirheumatic Agents / Antibodies, Monoclonal, Humanized / Anti-Inflammatory Agents Type of study: Clinical_trials / Etiology_studies / Guideline Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2015 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Arthritis, Rheumatoid / Triamcinolone / Methotrexate / Antirheumatic Agents / Antibodies, Monoclonal, Humanized / Anti-Inflammatory Agents Type of study: Clinical_trials / Etiology_studies / Guideline Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2015 Type: Article