PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase.

Clijsters, Linda; Wolthuis, Rob

Clijsters, Linda; Wolthuis, Rob.

Affiliation

Clijsters L; Division of Cell Biology (B5) and Division of Molecular Carcinogenesis (B7), The Netherlands Cancer Institute (NKI-AVL), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

J Cell Sci ; 127(Pt 6): 1336-45, 2014 Mar 15.

Article in En | MEDLINE | ID: mdl-24434580

Subject(s)

Cell Cycle Proteins/metabolism; Nuclear Proteins/metabolism; S Phase; Amino Acid Sequence; Antigens, CD; CDC2 Protein Kinase; Cadherins/metabolism; Cell Cycle Proteins/chemistry; Cell Line, Tumor; Cell Nucleus/metabolism; Conserved Sequence; Cyclin-Dependent Kinases/metabolism; DNA Replication; Humans; Nuclear Proteins/chemistry; Proteolysis; Ubiquitin-Protein Ligases/metabolism

Key words

CRL4Cdt2; Cdc6; Cdt1; Cell cycle; PCNA; PIP-box

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Full text: 1 Database: MEDLINE Main subject: Nuclear Proteins / S Phase / Cell Cycle Proteins Limits: Humans Language: En Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Nuclear Proteins / S Phase / Cell Cycle Proteins Limits: Humans Language: En Year: 2014 Type: Article