Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.

Kershaw, Nadia J; Laktyushin, Artem; Nicola, Nicos A; Babon, Jeffrey J

Kershaw, Nadia J; Laktyushin, Artem; Nicola, Nicos A; Babon, Jeffrey J.

Affiliation

Kershaw NJ; Division of Structural Biology, Walter and Eliza Hall Institute of Medical Research , Parkville, Victoria , Australia .

Growth Factors ; 32(1): 1-10, 2014 Feb.

Article in En | MEDLINE | ID: mdl-24438103

Subject(s)

Cytokine Receptor gp130/genetics; Janus Kinase 2/genetics; Suppressor of Cytokine Signaling Proteins/genetics; Suppressor of Cytokine Signaling Proteins/metabolism; Ubiquitin-Protein Ligases/genetics; Animals; Cell Line; Cloning, Molecular; Cullin Proteins/biosynthesis; Cullin Proteins/genetics; Cullin Proteins/metabolism; Cytokine Receptor gp130/metabolism; Elongin; Humans; Iron-Binding Proteins/biosynthesis; Iron-Binding Proteins/genetics; Janus Kinase 2/metabolism; Mice; NEDD8 Protein; Phosphorylation; Protein Binding; Signal Transduction/genetics; Spodoptera/cytology; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins/biosynthesis; Transcription Factors/biosynthesis; Transcription Factors/genetics; Ubiquitin-Conjugating Enzymes/biosynthesis; Ubiquitin-Conjugating Enzymes/genetics; Ubiquitin-Protein Ligases/biosynthesis; Ubiquitination/genetics; Ubiquitins/chemistry

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Full text: 1 Database: MEDLINE Main subject: Ubiquitin-Protein Ligases / Suppressor of Cytokine Signaling Proteins / Cytokine Receptor gp130 / Janus Kinase 2 Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Year: 2014 Type: Article

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