TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue, Satoshi; Tomasini, Richard; Rufini, Alessandro; Elia, Andrew J; Agostini, Massimiliano; Amelio, Ivano; Cescon, Dave; Dinsdale, David; Zhou, Lily; Harris, Isaac S; Lac, Sophie; Silvester, Jennifer; Li, Wanda Y; Sasaki, Masato; Haight, Jillian; Brüstle, Anne; Wakeham, Andrew; McKerlie, Colin; Jurisicova, Andrea; Melino, Gerry; Mak, Tak W

Inoue, Satoshi; Tomasini, Richard; Rufini, Alessandro; Elia, Andrew J; Agostini, Massimiliano; Amelio, Ivano; Cescon, Dave; Dinsdale, David; Zhou, Lily; Harris, Isaac S; Lac, Sophie; Silvester, Jennifer; Li, Wanda Y; Sasaki, Masato; Haight, Jillian; Brüstle, Anne; Wakeham, Andrew; McKerlie, Colin; Jurisicova, Andrea; Melino, Gerry; Mak, Tak W.

Affiliation

Inoue S; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

Proc Natl Acad Sci U S A ; 111(5): 1843-8, 2014 Feb 04.

Article in En | MEDLINE | ID: mdl-24449892

Subject(s)

DNA-Binding Proteins/metabolism; Fertility; Nuclear Proteins/metabolism; Spermatogenesis; Tumor Suppressor Proteins/metabolism; ADAM Proteins/genetics; ADAM Proteins/metabolism; ADAM17 Protein; Aging/pathology; Animals; Apoptosis/genetics; Cell Count; Cell Proliferation; DNA Damage/genetics; DNA-Binding Proteins/deficiency; Female; Fertility/genetics; Gene Expression Regulation; Humans; Infertility, Male/blood; Infertility, Male/genetics; Infertility, Male/pathology; Male; Matrix Metalloproteinase 13/genetics; Matrix Metalloproteinase 13/metabolism; Mice; Mice, Knockout; Nuclear Proteins/deficiency; Oxidative Stress/genetics; Progesterone/blood; RNA, Messenger/genetics; RNA, Messenger/metabolism; Spermatogenesis/genetics; Spermatozoa/metabolism; Spermatozoa/pathology; Testis/metabolism; Testis/pathology; Tumor Protein p73; Tumor Suppressor Proteins/deficiency

Key words

ADAM17; MMP13; Serpin; Timp

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Full text: 1 Database: MEDLINE Main subject: Spermatogenesis / Nuclear Proteins / Tumor Suppressor Proteins / DNA-Binding Proteins / Fertility Language: En Year: 2014 Type: Article

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