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A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity.
Rakonjac Ryge, Marija; Tanabe, Michiharu; Provost, Patrick; Persson, Bengt; Chen, Xinsheng; Funk, Colin D; Rinaldo-Matthis, Agnes; Hofmann, Bettina; Steinhilber, Dieter; Watanabe, Takashi; Samuelsson, Bengt; Rådmark, Olof.
Affiliation
  • Rakonjac Ryge M; Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77 Stockholm, Sweden.
  • Tanabe M; Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77 Stockholm, Sweden; Department of Neurosurgery, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago 6838504, Japan.
  • Provost P; CHUQ Research Center/CHUL, 2705 Blvd Laurier, Quebec, QC G1V 4G2, Canada; Faculty of Medicine, Université Laval, Quebec, QC G1V 0A6, Canada.
  • Persson B; Science for Life Laboratory, Dept of Cell and Molecular Biology, Uppsala University, Box 596, S-75124 Uppsala, Sweden.
  • Chen X; Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Funk CD; Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
  • Rinaldo-Matthis A; Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77 Stockholm, Sweden.
  • Hofmann B; Institute of Pharmaceutical Chemistry/ZAFES, University of Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.
  • Steinhilber D; Institute of Pharmaceutical Chemistry/ZAFES, University of Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.
  • Watanabe T; Department of Neurosurgery, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago 6838504, Japan.
  • Samuelsson B; Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77 Stockholm, Sweden.
  • Rådmark O; Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-171 77 Stockholm, Sweden. Electronic address: olof.radmark@ki.se.
Arch Biochem Biophys ; 545: 179-85, 2014 Mar 01.
Article in En | MEDLINE | ID: mdl-24480307

Full text: 1 Database: MEDLINE Main subject: Arachidonate 5-Lipoxygenase Limits: Humans Language: En Year: 2014 Type: Article

Full text: 1 Database: MEDLINE Main subject: Arachidonate 5-Lipoxygenase Limits: Humans Language: En Year: 2014 Type: Article