Long-lived intestinal tuft cells serve as colon cancer-initiating cells.

Westphalen, C Benedikt; Asfaha, Samuel; Hayakawa, Yoku; Takemoto, Yoshihiro; Lukin, Dana J; Nuber, Andreas H; Brandtner, Anna; Setlik, Wanda; Remotti, Helen; Muley, Ashlesha; Chen, Xiaowei; May, Randal; Houchen, Courtney W; Fox, James G; Gershon, Michael D; Quante, Michael; Wang, Timothy C

Westphalen, C Benedikt; Asfaha, Samuel; Hayakawa, Yoku; Takemoto, Yoshihiro; Lukin, Dana J; Nuber, Andreas H; Brandtner, Anna; Setlik, Wanda; Remotti, Helen; Muley, Ashlesha; Chen, Xiaowei; May, Randal; Houchen, Courtney W; Fox, James G; Gershon, Michael D; Quante, Michael; Wang, Timothy C.

J Clin Invest ; 124(3): 1283-95, 2014 Mar.

Article in En | MEDLINE | ID: mdl-24487592

Subject(s)

Adenocarcinoma/pathology; Colon/pathology; Colonic Neoplasms/pathology; Neoplastic Stem Cells/physiology; Adenocarcinoma/metabolism; Animals; Cell Lineage; Cells, Cultured; Colon/immunology; Colon/innervation; Colonic Neoplasms/metabolism; Diphtheria Toxin/pharmacology; Doublecortin-Like Kinases; Homeostasis; Intestinal Mucosa/immunology; Intestinal Mucosa/innervation; Intestinal Mucosa/pathology; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Protein Serine-Threonine Kinases/metabolism; Receptors, G-Protein-Coupled/metabolism

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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Adenocarcinoma / Colon / Colonic Neoplasms Limits: Animals Language: En Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Neoplastic Stem Cells / Adenocarcinoma / Colon / Colonic Neoplasms Limits: Animals Language: En Year: 2014 Type: Article