Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: relationship with multiple forms of drug ketone reductases.

Endo, Satoshi; Matsunaga, Toshiyuki; Arai, Yuki; Ikari, Akira; Tajima, Kazuo; El-Kabbani, Ossama; Yamano, Shigeru; Hara, Akira; Kitade, Yukio

Endo, Satoshi; Matsunaga, Toshiyuki; Arai, Yuki; Ikari, Akira; Tajima, Kazuo; El-Kabbani, Ossama; Yamano, Shigeru; Hara, Akira; Kitade, Yukio.

Affiliation

Endo S; Gifu Pharmaceutical University, Gifu, Japan (S.E., T.M., Y.A., A.I.); Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan (K.T.); Monash Institute of Pharmaceutical Sciences, Monash University, Victoria, Australia (O.E.); Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan (S.Y.); and Faculty of Engineering (A.H., Y.K.), Gifu University, Gifu, Japan.

Drug Metab Dispos ; 42(4): 803-12, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24510382

Subject(s)

Alcohol Oxidoreductases/metabolism; Aldehyde Reductase/metabolism; Pharmaceutical Preparations/metabolism; Xenobiotics/metabolism; Alcohol Oxidoreductases/antagonists & inhibitors; Alcohol Oxidoreductases/genetics; Alcohols/metabolism; Aldehyde Reductase/antagonists & inhibitors; Aldehyde Reductase/genetics; Aldehydes/metabolism; Aldo-Keto Reductases; Amino Acid Sequence; Animals; Cloning, Molecular; Isoenzymes; Ketones/metabolism; Ketosteroids/metabolism; Male; Molecular Sequence Data; Organ Specificity; Pharmaceutical Preparations/chemistry; Rabbits; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Sequence Alignment; Substrate Specificity; Xenobiotics/chemistry

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Full text: 1 Database: MEDLINE Main subject: Pharmaceutical Preparations / Xenobiotics / Aldehyde Reductase / Alcohol Oxidoreductases Limits: Animals Language: En Year: 2014 Type: Article

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