Arsenic trioxide during consolidation for patients with previously untreated low/intermediate risk acute promyelocytic leukaemia may eliminate the need for maintenance therapy.

Coutre, Steven E; Othus, Megan; Powell, Bayard; Willman, Cheryl L; Stock, Wendy; Paietta, Elisabeth; Levitan, Denise; Wetzler, Meir; Attar, Eyal C; Altman, Jessica K; Gore, Steven D; Maher, Tracy; Kopecky, Kenneth J; Tallman, Martin S; Larson, Richard A; Appelbaum, Frederick R

Coutre, Steven E; Othus, Megan; Powell, Bayard; Willman, Cheryl L; Stock, Wendy; Paietta, Elisabeth; Levitan, Denise; Wetzler, Meir; Attar, Eyal C; Altman, Jessica K; Gore, Steven D; Maher, Tracy; Kopecky, Kenneth J; Tallman, Martin S; Larson, Richard A; Appelbaum, Frederick R.

Affiliation

Coutre SE; Stanford University School of Medicine, Stanford, CA, USA.

Br J Haematol ; 165(4): 497-503, 2014 May.

Article in En | MEDLINE | ID: mdl-24528179

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Consolidation Chemotherapy; Leukemia, Promyelocytic, Acute/drug therapy; Adult; Aged; Aminoglycosides/administration & dosage; Aminoglycosides/adverse effects; Animals; Antibodies, Monoclonal, Humanized/administration & dosage; Antibodies, Monoclonal, Humanized/adverse effects; Antineoplastic Combined Chemotherapy Protocols/adverse effects; Arsenic Trioxide; Arsenicals/administration & dosage; Arsenicals/adverse effects; Biomarkers, Tumor; Cytarabine/administration & dosage; Cytarabine/adverse effects; Daunorubicin/administration & dosage; Daunorubicin/adverse effects; Disease-Free Survival; Dogs; Female; Gemtuzumab; Humans; Maintenance Chemotherapy; Male; Mercaptopurine/administration & dosage; Mercaptopurine/adverse effects; Methotrexate/administration & dosage; Methotrexate/adverse effects; Middle Aged; Oncogene Proteins, Fusion/blood; Oxides/administration & dosage; Oxides/adverse effects; Platelet Count; Remission Induction; Risk; Treatment Outcome; Tretinoin/administration & dosage; Tretinoin/adverse effects; Young Adult

Key words

acute promyelocytic leukaemia; leukaemia clinical; leukaemia trials; malignant haematology

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Full text: 1 Database: MEDLINE Main subject: Leukemia, Promyelocytic, Acute / Antineoplastic Combined Chemotherapy Protocols / Consolidation Chemotherapy Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Language: En Year: 2014 Type: Article

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