A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

Ahmed, Zeshan; Cooper, Jane; Murray, Tracey K; Garn, Katya; McNaughton, Emily; Clarke, Hannah; Parhizkar, Samira; Ward, Mark A; Cavallini, Annalisa; Jackson, Samuel; Bose, Suchira; Clavaguera, Florence; Tolnay, Markus; Lavenir, Isabelle; Goedert, Michel; Hutton, Michael L; O'Neill, Michael J

Ahmed, Zeshan; Cooper, Jane; Murray, Tracey K; Garn, Katya; McNaughton, Emily; Clarke, Hannah; Parhizkar, Samira; Ward, Mark A; Cavallini, Annalisa; Jackson, Samuel; Bose, Suchira; Clavaguera, Florence; Tolnay, Markus; Lavenir, Isabelle; Goedert, Michel; Hutton, Michael L; O'Neill, Michael J.

Affiliation

Ahmed Z; Eli Lilly and Company, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK, ahmedze@lilly.com.

Acta Neuropathol ; 127(5): 667-83, 2014 May.

Article in En | MEDLINE | ID: mdl-24531916

Subject(s)

Brain/pathology; Neurofibrillary Tangles/pathology; Tauopathies/pathology; tau Proteins/metabolism; Animals; Brain/metabolism; Disease Models, Animal; Disease Progression; Female; Hippocampus/metabolism; Hippocampus/pathology; Humans; Immunohistochemistry; Mice, Inbred C57BL; Mice, Transgenic; Neural Pathways/metabolism; Neural Pathways/pathology; Neurofibrillary Tangles/metabolism; Random Allocation; Synapses/metabolism; Synapses/pathology; Tauopathies/metabolism; Time Factors; White Matter/metabolism; White Matter/pathology; tau Proteins/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Brain / Neurofibrillary Tangles / Tau Proteins / Tauopathies Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Female / Humans Language: En Year: 2014 Type: Article

Fulltext

XML

PubMed Links

Search on Google