Pertussis toxin S1 mutant with reduced enzyme activity and a conserved protective epitope.

Burnette, W N; Cieplak, W; Mar, V L; Kaljot, K T; Sato, H; Keith, J M.

Affiliation

Science ; 242(4875): 72-4, 1988 Oct 07.

Article in En | MEDLINE | ID: mdl-2459776

Subject(s)

Mutation; Pertussis Toxin; Virulence Factors, Bordetella/genetics; Base Sequence; Bordetella pertussis/enzymology; Bordetella pertussis/genetics; Codon; Epitopes/genetics; Genes; Genes, Bacterial; NAD+ Nucleosidase/genetics; NAD+ Nucleosidase/metabolism; Operon; Poly(ADP-ribose) Polymerases/genetics; Poly(ADP-ribose) Polymerases/metabolism; Recombinant Proteins/metabolism; Virulence Factors, Bordetella/immunology; Virulence Factors, Bordetella/metabolism

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