In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma.

Sagiyama, Koji; Mashimo, Tomoyuki; Togao, Osamu; Vemireddy, Vamsidhara; Hatanpaa, Kimmo J; Maher, Elizabeth A; Mickey, Bruce E; Pan, Edward; Sherry, A Dean; Bachoo, Robert M; Takahashi, Masaya

Sagiyama, Koji; Mashimo, Tomoyuki; Togao, Osamu; Vemireddy, Vamsidhara; Hatanpaa, Kimmo J; Maher, Elizabeth A; Mickey, Bruce E; Pan, Edward; Sherry, A Dean; Bachoo, Robert M; Takahashi, Masaya.

Affiliation

Sagiyama K; Advanced Imaging Research Center, Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center, and Departments of Neurology and Neurotherapeutics, Pathology, Neurosurgery, and Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proc Natl Acad Sci U S A ; 111(12): 4542-7, 2014 Mar 25.

Article in En | MEDLINE | ID: mdl-24616497

Subject(s)

Antineoplastic Agents/therapeutic use; Brain Neoplasms/drug therapy; Dacarbazine/analogs & derivatives; Glioblastoma/drug therapy; Animals; Dacarbazine/therapeutic use; Humans; Mice; Mice, SCID; Prognosis; Temozolomide; Treatment Outcome; Xenograft Model Antitumor Assays

Key words

chemical exchange transfer imaging; chemoresistance; molecular MRI

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Full text: 1 Database: MEDLINE Main subject: Brain Neoplasms / Glioblastoma / Dacarbazine / Antineoplastic Agents Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Year: 2014 Type: Article

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