In vivo chemoembolization and magnetic resonance imaging of liver tumors by using iron oxide nanoshell/doxorubicin/poly(vinyl alcohol) hybrid composites.
Angew Chem Int Ed Engl
; 53(19): 4812-5, 2014 May 05.
Article
in En
| MEDLINE
| ID: mdl-24668846
ABSTRACT
A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an inâ
vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Polyvinyl Alcohol
/
Magnetic Resonance Imaging
/
Ferric Compounds
/
Doxorubicin
/
Chemoembolization, Therapeutic
/
Nanostructures
/
Liver Neoplasms
Limits:
Animals
Language:
En
Year:
2014
Type:
Article