Disseminated arterial calcification and enhanced myogenic response are associated with abcc6 deficiency in a mouse model of pseudoxanthoma elasticum.

Kauffenstein, Gilles; Pizard, A; Le Corre, Y; Vessières, E; Grimaud, L; Toutain, B; Labat, C; Mauras, Y; Gorgels, T G; Bergen, A A; Le Saux, O; Lacolley, P; Lefthériotis, G; Henrion, D; Martin, L

Kauffenstein, Gilles; Pizard, A; Le Corre, Y; Vessières, E; Grimaud, L; Toutain, B; Labat, C; Mauras, Y; Gorgels, T G; Bergen, A A; Le Saux, O; Lacolley, P; Lefthériotis, G; Henrion, D; Martin, L.

Affiliation

Kauffenstein G; From the CNRS UMR 6214, INSERM U1083, l'UNAM (G.K., Y.L.C., E.V., L.G., B.T., G.L., D.H., L.M.) and Laboratoire de Pharmacologie-Toxicologie, l'UNAM, Université d'Angers (Y.M.), University Hospital Angers, Angers, France; INSERM, U1116 (A.P., C.L., P.L.), Université de Lorraine, Vandoeuvre-lès-Nancy, France; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI (O.L.S.); Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience,

Arterioscler Thromb Vasc Biol ; 34(5): 1045-56, 2014 May.

Article in En | MEDLINE | ID: mdl-24675664

Subject(s)

ATP-Binding Cassette Transporters/deficiency; Arteries/metabolism; Calcium/metabolism; Elastic Tissue/metabolism; Pseudoxanthoma Elasticum/metabolism; Vascular Calcification/metabolism; Vascular Stiffness; Vasoconstriction; ATP-Binding Cassette Transporters/genetics; Animals; Arterial Pressure; Arteries/pathology; Arteries/physiopathology; Biomarkers/metabolism; Cell Transdifferentiation; Chondrogenesis; Collagen Type II/genetics; Collagen Type II/metabolism; Core Binding Factor Alpha 1 Subunit/genetics; Core Binding Factor Alpha 1 Subunit/metabolism; Disease Models, Animal; Elastic Tissue/pathology; Elastic Tissue/physiopathology; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Proteins; Osteogenesis; Osteopontin/genetics; Osteopontin/metabolism; Pseudoxanthoma Elasticum/genetics; Pseudoxanthoma Elasticum/pathology; Pseudoxanthoma Elasticum/physiopathology; RNA, Messenger/metabolism; Regional Blood Flow; SOXB1 Transcription Factors/genetics; SOXB1 Transcription Factors/metabolism; Vascular Calcification/genetics; Vascular Calcification/pathology; Vascular Calcification/physiopathology

Key words

ABC transporters; arteriosclerosis; calcification, physiologic

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Full text: 1 Database: MEDLINE Main subject: Arteries / Pseudoxanthoma Elasticum / Vasoconstriction / Calcium / ATP-Binding Cassette Transporters / Elastic Tissue / Vascular Calcification / Vascular Stiffness Type of study: Prognostic_studies / Risk_factors_studies Language: En Year: 2014 Type: Article

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