Measurement of the direct oral anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban in human plasma using turbulent flow liquid chromatography with high-resolution mass spectrometry.

Gous, Tracey; Couchman, Lewis; Patel, Jignesh P; Paradzai, Chitongo; Arya, Roopen; Flanagan, Robert J

Gous, Tracey; Couchman, Lewis; Patel, Jignesh P; Paradzai, Chitongo; Arya, Roopen; Flanagan, Robert J.

Affiliation

Gous T; *Toxicology Unit, Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust; Institute of Pharmaceutical Science, King's College London; and King's Thrombosis Centre, Department of Haematological Medicine, King's College Hospital NHS Foundation Trust, London, United Kingdom.

Ther Drug Monit ; 36(5): 597-605, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24695356

Subject(s)

Anticoagulants/blood; Chromatography, Liquid/methods; Mass Spectrometry/methods; Anticoagulants/chemistry; Benzimidazoles/blood; Benzimidazoles/chemistry; Dabigatran; Humans; Molecular Structure; Morpholines/blood; Morpholines/chemistry; Pyrazoles/blood; Pyrazoles/chemistry; Pyridines/blood; Pyridines/chemistry; Pyridones/blood; Pyridones/chemistry; Rivaroxaban; Thiazoles/blood; Thiazoles/chemistry; Thiophenes/blood; Thiophenes/chemistry; beta-Alanine/analogs & derivatives; beta-Alanine/blood; beta-Alanine/chemistry

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Full text: 1 Database: MEDLINE Main subject: Mass Spectrometry / Chromatography, Liquid / Anticoagulants Limits: Humans Language: En Year: 2014 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Mass Spectrometry / Chromatography, Liquid / Anticoagulants Limits: Humans Language: En Year: 2014 Type: Article