Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts.

Chen, Jian-Yu; Zhang, Lei; Zhang, Hong; Su, Li; Qin, Lu-Ping

Chen, Jian-Yu; Zhang, Lei; Zhang, Hong; Su, Li; Qin, Lu-Ping.

Affiliation

Chen JY; Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, PR China; Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai, 200433, PR China.

Phytother Res ; 28(10): 1468-78, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24706573

Subject(s)

Apoptosis/drug effects; Cicatrix, Hypertrophic/pathology; Fibroblasts/cytology; Mitochondria/drug effects; Oleanolic Acid/pharmacology; Signal Transduction/drug effects; Anthracenes/pharmacology; Apoptotic Protease-Activating Factor 1/metabolism; Caspase 3/metabolism; Caspase 9/metabolism; Cell Line; Cytochromes c/metabolism; Fibroblasts/metabolism; Humans; Imidazoles/pharmacology; MAP Kinase Signaling System; Membrane Potential, Mitochondrial/drug effects; Phosphorylation; Proto-Oncogene Proteins c-bcl-2/metabolism; Pyridines/pharmacology; bcl-2-Associated X Protein/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

apoptosis; fibroblast; mitochondria; natural product; signaling pathway

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Full text: 1 Database: MEDLINE Main subject: Oleanolic Acid / Signal Transduction / Cicatrix, Hypertrophic / Apoptosis / Fibroblasts / Mitochondria Limits: Humans Language: En Year: 2014 Type: Article

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